Sentence examples for by mutations that modify from inspiring English sources
Recently the function of yeast PCNA was found to be highly affected by mutations that modify its affinity for several of its other protein partners, with higher affinities causing deficiencies in DNA replication and DNA repair more severe than binding abolishment [36].
The genes that control these developmental processes are known to be highly conserved [ 36] and it is believed that adaptive evolutionary change is fueled by mutations that modify the expression of these conserved regulatory loci [ 36, 37].
This stepwise progression is in part driven by the acquisition of genetic mutations that modify the function of cancer-related proteins [ 2].
They generally adapt to these challenges through genetic mutations that modify features they already have.
The agonist affinity can be modified by mutations that cause a structural change in the binding site, or when an agonist-specific binding residue is altered.
In a screen for mutations that modify wg loss-of-function phenotypes, we isolated multiple independent alleles of ck.
Most of the mutations are in proteins that modify histones, which are the proteins that the DNA is wrapped around, often represented as packages of round beads bound together by strands of DNA.
The aim of this study was to identify novel genes involved in auxin signal transduction by screening for second site mutations that modify the axr3-1 gain-of-function phenotype.
Women who have mutations that modify risk may well be interested in tailoring their preventive medical management to an adjustment in risk.
Genetic studies examining seemingly healthy people have revealed, for example, rare mutations in chemokine (C-C motif) receptor type 5 (the co-receptor for human immunodeficiency virus) that block HIV infection (8), and secondary mutations in fetal globin genes that modify the severity of sickle cell disease by buffering primary mutations in β-globin genes (9).
It is caused by mutations in the gene encoding OCRL, a protein that modifies a membrane lipid and that is found on membranes transporting molecules (cargo) into cells by a process known as endocytosis.
