Sentence examples for by mutations in various from inspiring English sources

Any hope for amelioration lies in understanding the general functional processes that are disrupted by mutations in various pathways.

From the literature, we knew the Rcs system was affected by mutations in various genes, by overexpression of additional genes, or in response to environmental signals [37], [38], [39].

In line with its suppressive function on oncoproteins, SCFFbxw7/hCdc4 is inactivated by mutations in various tumor types [ 4].

In P. putida KT2440, colonization of seeds was affected by mutations in various genes (Yousef-Coronado et al., 2008).

HCM is highly prevalent, affecting 1 500 of the population and can be caused by mutations in various sarcomeric protein encoding genes (Maron and Maron, 2013).

The seven different types of mucopolysaccharidoses are very rare diseases caused by autosomal recessive mutations in various lysosomal enzymes involved in the breakdown of mucopolysacccharides. Type I mucopolysaccharidosis is caused by deficient lysosomal breakdown of glycosaminoglycans and the consequent accumulation of heparan sulfate and dermatan sulfate throughout the body.

The genes most commonly affected by sporadically acquired point mutations in various types of cancers are in the ras gene family.

The vital role that the microtubule cytoskeleton plays in these cellular processes is reflected by the discovery that mutations in various tubulin isotypes cause different neurodevelopmental diseases, including lissencephaly (TUBA1A), polymicrogyria (TUBA1A, TUBB2B, TUBB3), and an ocular motility disorder (TUBB3).

Constitutive activation of WNT/ β-catenin signalling in cancer is caused by a variety of mutations in various components of the pathway, leading either to inactivation of APC, axin/conductin or β-TrCP or to oncogenic activation of β-catenin.

These clinical observations have been corroborated over the past few years by the demonstration that JATD can be caused by mutations in genes that encode various ciliary proteins, which justifies the classification of JATD as a skeletal ciliopathy (2).

In a similar way, by examining the PCD phenotype of mutations in various ciliary proteins, identified by proteomics, it should be possible to dissect details of the function of the protein in the mechanism of beat generation (Avidor-Reiss et al. 2004; Badano et al. 2006; Blacque et al. 2005).