Sentence examples for by mutations in single from inspiring English sources

There are hundreds of rare heritable diseases but the number of people affected is relatively small – only 4% of the population is born with genetic diseases caused by mutations in single genes (rather than being affected by a number of genes, such as breast cancer) and, because the number of people affected is small, there are far fewer treatments.

Many are known to be caused by mutations in single genes, yet for the vast majority no treatments are available.

Simple (or Mendelian) diseases such as sickle cell anemia and cystic fibrosis are caused by mutations in single genes.

Conversely, there is no reason to assert that rare diseases will be totally explicable by mutations in single genes or rare variants.

This is crucial, since most cases of chronic diseases are not caused by mutations in single genes but rather by complex interactions among variants of several... genes".

The critical role of hair-keratins in hair biology is revealed by the fact that a variety of epidermal diseases are caused by mutations in single hair-keratin genes [ 5].

Some of the earliest work has until now been with inherited diseases caused by mutations in a single gene.

It is one of the spectrum of autistic disorders, but unlike most of the others it is caused by mutations in a single gene.

Some diseases, like sickle cell anemia or cystic fibrosis, are caused by mutations in a single gene, and are relatively rare.

Such information would allow detection of so-called Mendelian disorders, like cystic fibrosis, Tay-Sachs disease and Marfan syndrome, which are caused by mutations in a single gene.

For diseases caused by mutations in a single gene, the therapeutic goal is tissue replacement using stem cells engineered to correct the genetic defect.