Sentence examples for by mutations in key from inspiring English sources

This effect can be alleviated by mutations in key amino acids of the U-binding pocket.

However, malignant progression of early lung lesions in the V600EBRAF model can be facilitated by mutations in key genes including depletion of tumour suppressor TRP53 (Dankort et al, 2007) or constitutive activation of β-catenin (Juan et al, 2014), indicating that these early lesions are indeed precursors for adenocarcinomas.

It is commonly upregulated in tumours by mutations in the key pathway components APC and CTNNB1.

This organization depends on heterochromatin (Ekwall et al, 1996; Alfredsson-Timmins et al, 2007) and can also be affected by mutations in the key factors of RNAi (ago1, dcr1 and rdp1) (Hall et al, 2003).

In a bid to harness this potential fuel source, Thomas Wood, a chemical engineer at Texas A&M University, revved up hydrogen yields by inducing mutations in key metabolic pathways.

Hereditary inclusion body myopathy (HIBM) is a rare neuromuscular disorder caused by mutations in GNE, the key enzyme in the biosynthetic pathway of sialic acid.

Bert Vogelstein and Kenneth Kinzler, who co-direct a lab at the Johns Hopkins University medical campus, helped lay the foundation of cancer genetics by revealing how mutations in key genes lead to a tumor.

Yet, these networks are also poised such that they can be dynamically reorganized toward new purposes by only a few mutations in key enzymes and regulatory proteins.

Cancer has been traditionally typified by a stepwise accumulation of mutations in key oncogenes and tumor suppressors [ 1].

An increase in lactate is also seen in adequately oxygenated cells when respiration is inhibited either by respiratory poisons or null mutations in key respiratory enzymes (69 71).

Our data suggest that during GS evolution, there is accumulation of complementary mutations in key cellular processes through recursive genetic recombination or by the accumulation of single mutations in crucial genes that confer a fitness advantage.