For example, mutational changes can be easily restricted to the inner tepals and lip by mutations in a clade 3 gene, or to the lip by mutations in a clade 4 gene.
The condition, MCAD deficiency, is caused by mutations in a gene involved in fat metabolism.
Some of the earliest work has until now been with inherited diseases caused by mutations in a single gene.
Some diseases, like sickle cell anemia or cystic fibrosis, are caused by mutations in a single gene, and are relatively rare.
Duchenne muscular dystrophy is caused by mutations in a gene on the X chromosome and affects around one in 3,500 boys.
It is one of the spectrum of autistic disorders, but unlike most of the others it is caused by mutations in a single gene.
It is caused by mutations in a gene called ABCA4 (ATP-binding cassette, subfamily A, member 4).
And what was once considered a mild form of hemophilia was later identified as a variant of a different clotting disorder, von Willebrand disease, caused by mutations in a different gene and requiring a different clotting factor as treatment.
In 1971 American researcher Alfred Knudson, Jr., postulated that a rare form of eye cancer called retinoblastoma is caused by mutations in a gene designated RB.
Such information would allow detection of so-called Mendelian disorders, like cystic fibrosis, Tay-Sachs disease and Marfan syndrome, which are caused by mutations in a single gene.
Sorsby fundus dystrophy, which is clinically similar to wet AMD, is caused by mutations in a gene known as TIMP3 (tissue-inhibitor of metalloproteinase 3).
