Sentence examples for by mutational study of from inspiring English sources

Synthetic polypeptides generated by mutational study of this 37-amino acid intracellular domain were used to identify the homologous 17-amino acid sequence, RRNHQEESNIGKHRELR, responsible for these binding capacities (21) and were necessary and sufficient for the activation of G proteins and effector enzymes (23).

S141, Y154 and K158 are displaced and form hydrogen-bond contacts with the backbone carbonyl groups of P184 and M246, thus preventing interactions for binding of the ribose moiety of NADPH as seen in the holoenzyme and shown to be critical for its efficient binding by mutational studies of E. coli FabG.

► Mutational study of the ion gate of Mg2+ transporter CorA.

In addition, the close interconnection of both trajectories is also mirrored by mutational studies that identified two conserved amino acids in the I-helix region of AOS.

The transport specificity in water-specific AQP channels have been clearly demonstrated by using mutational studies of three aromatic/Arginine (ar/R) constriction region residues F56, H180 and R195 rat AQP1.

The importance in binding of the conserved glutamine and of the two flanking residues was demonstrated by mutational studies [37].

The importance of this amino acid for the p53-MDM2 isteralsoon is also well documented by mutational studies.

Herein, we report a 2.9 Å structure of the eArgRS-L-arginine complex (PDB ID: 4OBY) and a series of mutational studies of the enzyme active site.

The mechanism of protein folding has been addressed with mutational studies of folding rates and equilibrium constants.

Structural and mutational studies of the CARD domains of Apaf-1 and procaspase-9 have identified the essential motifs for procaspase-9 activation by Apaf-1 [34].

Based on the conserved motifs, eight important residues were identified for the mutational studies of FadD13.