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The GPI-anchored CEACAMs, which have been identified so far only within primate CEA families, were generated by mutational modification of a transmembrane domain exon in a CEACAM1-like ancestor [ 8].
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The continuing mutational modification of H1N2 and H3N2 have resulted in entropy patterns distinctive of the human transmitted influenza A viruses with a large number of amino acid sequence patterns that differ from those of the avian to avian counterpart.
Chemical or mutational modification of the zinc-coordinating ligands in isoleucyl-tRNA synthetase (of E. coli and Thermus thermophlilus) affects the enzyme efficiency [ 5, 6].
Considerations of mutational modifications demonstrate how a GATA3 positive cancer may actually produce a distinct clinical phenotype.
Reduced protein expression of mutein PaHNL5-L1Q-A111G was remedied by mutational anticipation of posttranslational deamidation.
Disruption of these processes by inappropriate regulatory signals and by mutational rewiring of the network can lead to tumorigenesis.
Aberrant activation of the EGFR pathway sometimes occurs by mutational activation of KRAS.
This is congruent with the results obtained by mutational analysis of the PA-binding domain [28].
These new mutations could cause a modification of the mutational landscape and reveal new pairs of SL, of course only in the treated patient sets.
However, at that time, there had only been limited characterization of patterns of mutations imprinted by mutational processes.
Therefore, we examined by mutational analyses the reason for the resistance of human SNAP-23, an isoform of SNAP-25.
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