Sentence examples for by mutational analysis and from inspiring English sources

This 'hybrid' model (based on experimental and computational constraints) was corroborated by mutational analysis and correctly predicted cancer patient-derived p85α mutations that disrupt the p85α PTEN-interacting interface.

The regulation of EcR on insect development has been well demonstrated by mutational analysis and by using inducible expression of double stranded RNA (dsRNA) of EcR isoforms in D. melanogaster, which resulted in a block in neuronal remodeling and ecdysone responses during larval molting and metamorphosis [25], [26], [27], developmental arrest during embryogenesis and failure of pupation [28].

We wanted to test this possibility by mutational analysis and mapped the interaction sites between SLP65 and CIN85/CD2AP.

The arrangements of MotA and MotB within the complex have been studied extensively by mutational analysis and systematic disulfide cross-linking studies.

Single amino acids determining the sensitivity of L-type channels for calcium antagonists have been identified by mutational analysis and functional studies (Hering et al., 1996; Kraus et al., 1998; Striessnig et al., 1998, Berjukow et al., 1999 Hockerman et al., 2000; Dilmac et al., 2003).

Genes controlling developmental and metabolic processes have been discovered in plants by mutational analysis (Miroslaw and Iwona 2003).

Comparative genomic hybridization followed by mutational analysis, gene expression and miRNA microarray profiling were performed on 123 paired tumor and non-tumor tissue samples from patients with NSCLC.

The role of the ribosomal tunnel in the SecM stalling process was highlighted by mutational analysis of the L4 and L22 proteins and the 23S rRNA [ 24, 47, 48].

We found that 7/11 (64%) mutated patients showed the same mutation found by mutational analysis without LCM in at least 1 area.

The receptor binding domains to both VEGF-R2 and VEGF-R3 have also earlier been analyzed by mutational analysis of VEGF-C and these data correlate well with the structural results for VEGF-R2 [24].

We validated the crystallographic BH dimer model by mutational analysis (see main text and Figure 1G).