Sentence examples for by mutant forms of from inspiring English sources

If so, this might suggest that pyrin, a known regulator of inflammasome function, is etiologically linked to the pathogenesis of inflammatory diseases caused by mutant forms of both PSTPIP1 and PSTPIP2.

To explore the effect of PAPA mutations on the PSTPIP1 pyrin interaction, we next tested whether the filaments formed by mutant forms of PSTPIP1 could be reorganized by pyrin.

The loss of this repressive function by mutant forms of p53 (R280K, R280K) is accompanied by enhanced Nox4-derived ROS, cell migration, and FAK activation, which further elucidate the invasive behaviour commonly associated with p53 mutations.

Moreover, the Rac GEF activity, in particular Rac1/PI3K/Akt3 pathway, is involved in Alsin-regulated protective effects against motoneuron death induced by mutant forms of SOD1 (superoxide dismutase 1), another causative gene in ALS [ 120, 127].

To elucidate the role of this acetylation, the endogenous BubR1 was substituted by mutant forms of BubR1 that either could not be acetylated (K25R) or had the lysine replaced by glutamine to mimic acetylation (K250Q).

This study thus provides the most comprehensive picture to date of the proinflammatory signalome that is constitutively activated by mutant forms of TNFR1, even in TRAPS patients being treated with glucocorticoids and/or cytokine-blocking biologics.

This hypothesis is supported by our data showing the antagonistic effect of LPA on the LEF/TCF-dependent transcription induced by mutant form of β-catenin, β-catenin-ΔGSK-GFP (Figure S6).

This suggests impaired ability to form stable complexes between the adaptor protein ankyrin R and its interacting partners in the Purkinje cell dendritic tree is a key mechanism by which mutant forms of β-III spectrin cause ataxia, initially by Purkinje cell dysfunction and exacerbated by subsequent cell death.

Some of the effects that we observe in larval wing discs may be attributed to titration of regulatory factors by the mutant forms of Armadillo, as has been reported elsewhere [4], [34].

To further compare SUMO binding by SIM mutant forms of Pc2 we tested interaction of GST-SUMO1 or GST-SUMO2, purified from bacteria, with Flag-tagged Pc2 expressed in COS1 cells.

In fact, the same results have been obtained by using mutant forms of K-Ras, known to induces resistance to IM [19], in 32Dp210BCR-ABL cells as well as in a CML patient sample with a weakly activating T58I K-Ras mutation, (Figure S4).