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Choueiri et al identified 5 clinical factors by multivariate analysis that predicted for progression-free survival in patients treated with the antiangiogenesis agents sunitinib, sorafenib, axitinib, or bevacizumab.
Three biomarkers – IL-8, intercellular adhesion molecule 1 and protein C – remained significantly different by multivariate analysis that included age, gender, Simplified Acute Physiology Score II and all biomarkers that were significant on bivariate analysis.
Sohn et al (2000) showed by multivariate analysis that negative resection margins, tumour size and differentiation were important independent prognostic indicators.
A review of published randomised trials in which the glucocorticoid protocol was defined found by multivariate analysis that glucocorticoid withdrawal was the strongest predictor for relapse [ 52].
A retrospective observational study of 461 OOHCA patients identified, by multivariate analysis, that a glucose level of greater than 10.6 mmol/L within the first 24 hours after admission was associated with significantly higher hospital mortality [ 97].
Using both immunoblotting and IHC, it has been shown by multivariate analysis that pErk was a marker for prolonged survival [ 45], while others have reported that pErk independently predicted for reduced survival [ 46, 47].
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Bivariate analyses were conducted first, followed by a multivariate analysis that initially included all bivariate factors with p < 0.10, and then backwards elimination to obtain a final model with factors significant at the 0.05 level.
Interestingly, it was shown by both univariate and multivariate analysis that c- myc, but not her-2/ neu, was associated with poor disease-free survival (DFS).
The NLSY79 is used to compare the distance of onward and return migrations by Hispanics, blacks and whites in a multivariate analysis that controls characteristics of migrants and of places of destination and origin and age, education, marriage, length of residence, employment, income.
35, 37 This was supported in one study by a multivariate analysis that identified chemotherapy as the only prognostic factor for OS in asymptomatic patients, and in the other by the fact that the advantages of primary tumor resection in asymptomatic patients are outweighed by perioperative mortality.
An Estonian study of 406 patients treated by radical gastrectomy found in a multivariate analysis that in addition to stage, nodal status, extent of gastrectomy and age; papillary, tubular and undifferentiated tumours offered better survival (Arak and Kull, 1994).
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