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Aït-Aïssa et al. [ 74] confirmed by multivariate analyses that some correlation exists between these biomarkers and concluded the use of complementary biomarkers as necessary to discriminate between different treatments and to highlight interactive effects.
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SPSS version 12 (SPSS, Chicago, IL) was used for statistical analyses, except for multivariate analyses that were performed by "R" version 3.0.2.
By multivariate analyses, we showed that Aurora B overexpression was associated with high-stage (stages IIIA, IIIB, and IV) HCC, which exhibits vascular invasion and various extent of microscopic intrahepatic spread (OR, 7.439; P = 0.0003).
To extract information from those patterns, the preliminary assessments based on Procrustes distances are usually followed by multivariate analyses of individual variation and asymmetry that can address a wide range of biological questions [ 11, 18, 21, 24, 30, 33, 53- 56].
Wethen performed RT-quantitative PCR gene expression in PBMCs on independent cohorts,followed by multivariate analyses to identify interrelated gene sets that can differentiate responders from non-responders to infliximab therapy in an independent cohort.
Second, individual profiles were also investigated by multivariate analyses because it is a band-based approach that does not assume Hardy-Weinberg equilibrium.
Relative risks (RRs) and 95% confidence intervals (CIs) of stroke by treatment exposures were examined by multivariate analyses.
Risk factors contributing to suicidality by multivariate analyses are documented in Table 3.
Odds ratios (OR) and their 95% confidence intervals (CI) were estimated by multivariate analyses.
The results are confirmed by multivariate analyses.
The significant risk factors were then tested by multivariate analyses.
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