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The primary outcome of the model was to estimate the potential gain in Hearing Level in decibels (dBHL) associated with each strategy and express this in terms of QALY, which was estimated as a linear function by multiplying a utility value per unit increase in dBHL with the total potential gains in dBHL over two pre-defined time periods of 12 and 24 months.
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A QALY is calculated by multiplying the utility of being in a certain health state by the time a patient experiences that health state.
QALYs will be calculated by multiplying the utility of a health situation by the time spent in these health situations.
QALYs will be calculated by multiplying the utility of a health state by the time spent in this health state, based on the Dutch valuation tariff [ 39].
Quality adjusted life years (QALY's) will be calculated by multiplying the utility of a health state by the time spent in this health state.
Quality-adjusted life-years (QALYs) will be calculated by multiplying the utility of a health state by the time spent in this health state using linear interpolation between time points.
The EQ-5D scores will be used to calculate utilities using the Dutch tariff [ 30 ]. Quality-adjusted life-years (QALYs) will be calculated by multiplying the utility of a health state by the time spent in this health state using linear interpolation between time points.
QALYs are calculated by multiplying the utility level for a given disease status (a health-related quality-of-life weight ranging between 0 and 1) with the number of years an individual suffers from that disease.
We derived utilities for each health state by multiplying these baseline utility values by utility estimates for women with early-stage breast cancer [ 41, 52- 55] (Table 2).
QALYs are calculated by multiplying the utility with the amount of time a patient spent in a particular health state.
QALYs will be calculated by multiplying the utility by the amount of time a patient spent in a particular health state.
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