But GnRH is in turn relegated by many chemical triggers, including leptin, produced by fat.
Cellular senescence can be triggered by multiple mechanisms including induction of the INK4a/ARF locus, telomere attrition, DNA damage, oxidative damage and the aberrant proliferative signals of oncogenes (reviewed in Collado & Serrano, 2006).
This irreversible cytostatic state can be triggered by multiple mechanisms, including telomere shortening, oxidative stress, cancer-causing genetic alterations, and DNA damage [1], [2].
In-vitro studies demonstrate that exocytosis of WPBs can be triggered by multiple secretagogues, including thrombin, histamine, epinephrine, VEGF, and hypoxia [ 13].
Rearrangements are triggered by multiple events including external factors such as cellular stress and incorrect DNA repair or recombination (Mani and Chinnaiyan, 2010).
The choice of UV to induce apoptosis is due to the fact that UV induces apoptosis by multiple processes including DNA damage, activation of the tumor suppressor gene p53, triggering of cell death receptors either directly by UV or by autocrine release of death ligands, mitochondrial damage, and cytochrome c release (Kulms and Schwarz 2000).
When the normal epithelial cell loses cellular contact with the ligands in the extracellular matrix, it will undergo a specific type of programmed cell death (i.e., anoikis) triggered by multiple protein kinases/phosphatase including phosphoinositide-3 kinase (PI3K), extracellular signal-regulated kinase (ERK), and Jun N-terminal kinases (JNKs) [ 20].
It's a spectre that is brought up by multiple speakers, including Lazarus, in Ipswich.
The overall PPV of a trigger tool is influenced by the interpretation of the trigger definitions, the number of triggers included, and how multiple occurrences of the same trigger have been dealt with.
All triggers included in the HAE PRO questionnaire were confirmed by at least one patient.
