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In addition, the rapid responses to hypoxia are mediated by multiple transduction pathways activated also upon GPER stimulation [ 67, 68].
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Expression analyses suggested that maize CDPK genes are important components of maize development and multiple transduction pathways.
In response to different signals, multiple transduction pathways and targets are activated to induce cellular senescence responses.
Plant response to pathogens is regulated by multiple signal transduction pathways, in which SA functions as key signaling molecules [ 15, 38].
SNS suppresses the invasiveness and metastatic potential of hepatocellular carcinoma cells by inhibiting multiple signal transduction pathways.
Under homeostatic conditions, ROS are critical to multiple signal transduction pathways by acting as second messengers.
Activation of the Ras oncogene is accompanied by the stimulation of multiple signal transduction pathways leading to the activation or repression of numerous transcription factors as well as changes in mRNA translation and stability, and thus, the modulation of gene expression.
Multiple signal transduction pathways are activated by the binding of ephrins to Eph receptors, leading to actin rearrangements that can promote dendritic spine formation and maturation as well as spine retraction and loss [3], [8], [56], [58] [60].
17-AAG, by virtue of its effects on multiple signal transduction pathways, may therefore overcome resistance to molecular targeted therapy.
It was hypothesized that inhibition of multiple signal transduction pathways in ABC by a multitargeted kinase inhibitor would translate into a long-term efficacy benefit superior to that of a single-agent fluoropyrimidine.
Moreover, the existence of multiple G-type proteins in sensory epithelium suggests that multiple signal transduction pathways may be activated following ligand stimulus.
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