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Asthma is a common and chronic disorder of the airways induced by multiple stimuli including exposure to allergens, particulates and infectious agents.
Insulin secretion from pancreatic β-cells is a highly dynamic process regulated by multiple stimuli, including nutrients, hormones, and neuronal inputs.
β-cell apoptosis can be induced by multiple stimuli including proinflammatory cytokines and long chain NEFAs in both type 1 and type 2 diabetes [ 9, 34].
NKG2DL expression is highly restricted in healthy tissues, but can be stimulated by multiple stimuli, including infection and heat shock, and by cellular transformation [ 12].
The kinase activity of RIPK1 is required for necroptosis as induced by multiple stimuli, including death receptor ligation in the presence of caspase inhibitors.
At the transcriptional level, almost all IAP proteins are driven by the upstream transcription factor NF-kappa B (NF-κB), which can be stimulated by multiple stimuli, including TRAIL [ 19].
Similar(51)
It is characterized by typical unilateral, often severe, pain throbbing with associated features such as hypersensitivity to multiple stimuli, including visual (photophobia), auditory (phonophobia), and sensory (cutaneous allodynia) stimuli during migraine attacks [1].
Cellular microenvironments present cells with multiple stimuli, including not only soluble biochemical and insoluble matrix cues but also mechanical factors.
Indeed, a report by Nasta et al. [ 20] showed that PARP-1 deficiency does not affect production of IL-17 in response to multiple stimuli including CD3 and CD28.
The NF-κB family of transcription factors are similarly activated by multiple stimuli that include DNA damage and ROS.
The expression of the pld gene is regulated by multiple environmental stimuli, including heat, and plays a role in the reduction of macrophage viability following infection [ 78, 79].
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