Sentence examples for by multiple repair pathways from inspiring English sources
These lesions cause distortions in the DNA that can be recognized by multiple repair pathways.
A model is now emerging in which phosphorylation of Brca1 by ATM recruits or regulates multiple repair pathways that may involve the hRad50-hMre11-p95/nibrin complex, transcription coupled repair, or Rad51-mediated homologous recombination [ 34].
The involvement of ERCC1/XPF as a nuclease in multiple repair pathways in addition to NER (interstrand crosslink repair and DSB repair) raises the question whether the neurodegenerative changes observed were caused by deficiency in one of these pathways, or by synergistic deleterious actions resulting from defects in multiple pathways [ 26, 65].
Our results are consistent with a class switch recombination model in which AID-catalyzed uridines are processed by multiple DNA repair pathways.
SLX4 is a novel member of the FA genes that coordinates multiple DNA repair pathways by acting as a scaffold for multiple nucleases involved in ICL repair and the mechanisms involved in HR [ 28].
In their article, Guoqi Liu and Michael Leffak [ 12] debate how collaborative efforts by the replication machinery and multiple DNA repair pathways stabilize (CAG n and (CTG n trinucleotide repeats.
Although FUS is associated with multiple genome repair pathways, its role in the DDR is not completely understood.
The repair of MMC-induced DNA lesions involves multiple DNA repair pathways, with HR and other HR-dependent DNA repair pathways, i.e. Fanconi anaemia (FA) and nucleotide-excision repair (NER), being the main repair pathways [19].
It is unknown which DNA repair pathway mediates repair of the integration intermediate in vivo, but proteins from multiple DNA repair pathways are able to repair a similar substrate in vitro [2].
We have shown that variations in multiple DNA repair pathways show association with the primary immunodeficiency syndromes CVID and IgAD.
Multiple DNA repair pathways are employed during doublestrand break repair.
