At individual sites, Tup1-Ssn6 is recruited simultaneously by multiple proteins and is likely forming a multi-meric complex containing Tup1, Ssn6, multiple recruiting proteins, and chromatin remodeling factors.
Recently, Kurokawa et al. reported overexpression of eukaryotic proteins containing multiple disulfide bonds by coexpression with Dsb protein [ 19, 20].
The organization of these networks is regulated by proteins containing multiple protein protein interaction domains such as PDZ domains, GuK domains, SH2 or SH3 domains (Pawson and Nash 2003).
The effects of c-Abl are mediated by multiple protein-protein and protein-DNA interactions and its tyrosine kinase domain.
By contrast, there are several proteins containing multiple Armadillo (Arm) repeats (PF00514), of which at least one could be a candidate for a β-catenin homologue (see below).
Scaffolding proteins containing multiple protein interaction motifs are thought to provide the framework of the PSD through their interactions with both membrane proteins and the cytoplasmic proteins.
This is particularly problematic for proteins containing multiple sites of phosphorylation, as each could be independently modulated by different kinases or phosphatases as a function of various stimuli.
Furthermore, many of these proteins contain multiple disorder-based protein interaction sites.
Additionally, almost all of ChW proteins contain a multiple of three ChW domains.
Signaling proteins contain multiple functional components and multiple sites of post-translational modification.
For the analysis, we have adjusted the total number of viral proteins contained in the UniProt database, since in the proteomes of different viruses, multiple fragments of the same proteins had multiple representation.
