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Similar to T2DM, diabetic complications are complex phenotypes determined by multiple pathways with a large genetic component.
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Because the kinases acting at these residues are distinct and may be functioning through different pathways, it is reasonable to speculate that regulation of stathmin phosphorylation can be achieved by multiple pathways, thus providing the cell with a finely tunable mechanism for controlling microtubule assembly and dynamics in relation to its needs.
Since STAT5 is activated by multiple pathways (Lim and Cao, 2006), genes bound by STAT5 alone may represent interplay with alternative kinases, modifying distinct sites on histones.
In vivo studies often summarize effects caused by multiple pathways of endocrine and other reproductive toxicities.
Dapoxetine is metabolized by multiple pathways, and no clinically relevant drug drug interactions have been identified.
They mediate their immunosuppressive effects by multiple pathways [ 198].
MDM2 phosphorylation at Ser166 is regulated by multiple pathways.
Lipid metabolism is controlled by multiple pathways and influenced by multiple genes.
High expression of multiple cytokines suggests that tumour angiogenesis is activated by multiple pathways.
By gene array, we found consistent alterations in multiple pathways with known relationship to PAH, including actin organization, immune function, calcium balance, growth, and apoptosis.
Switchgrass ranges from Quebec to Central America and, like maize, is a C4 species, fixing carbon by multiple metabolic pathways with high water use efficiency [ 3, 4].
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