This literature suggests that RA may be caused by multiple pathways, each of which is expressed in a slightly different manner in each individual [ 24].
The antineoplastic effects are mediated by multiple pathways including suppression of COX-2, inhibition of the antiapoptotic B-cell lymphoma-2 (Bcl-2)/Bcl-extra-large (Bcl-XL) family and cyclin E1, and activation of p53 [ 27].
The final biochemical events that occur in fibrosis may be triggered by multiple pathways, and dissection of the aberrant regulation of extracellular matrix deposition in SSc and other CTDs represents an immediate challenge for translational research.
We reason that this repeat sequence has been transferred by multiple pathways as part of the pervasive mobilome that actively shapes the genomic makeup of selected microorganisms.
EMT can be initiated by multiple pathways converging in the activation of EMT inducers.
Thus the extent of translational up-regulation attained through the concerted activation of mTOR by multiple pathways in 293T could be achieved through its activation primarily by the PA pathway in PC3.
The 15 signaling effectors employed in this study were specifically chosen as they are critical signaling nodes activated by multiple pathways and are likely candidates as indicators of activation in multiple cell populations.
Tetrac and its nanoparticulate formulation are potent antagonists of VEGF actions by multiple pathways [ 16, 17].
However, since angiogenesis is driven by multiple pathways, measuring only one individual circulating protein of a single pathway might not be sufficient.
Similar to clustering algorithms, co-regulation of individual genes by multiple pathways and transcription factors will bias these gene set-based analysis techniques [ 18].
