Shimizu A, Nakayama H, Wang P, König C, Akino T, Sandlund J, Coma S, Italiano JE, Mammoto A, Bielenberg DR, Klagsbrun M. Netrin-1 promotes glioblastoma cell invasiveness and angiogenesis by multiple pathways including activation of RhoA, cathepsin B, and cAMP-response element-binding protein.
The stability of Skp2 protein is regulated by multiple pathways, including phosphorylation and proteasomal degradation.
Next, we examined the biological effect of Salmonella infection expression on epithelial proliferation, which is regulated by multiple pathways, including the Akt and EGF pathways.
Agonist-induced Ca2+ signals are controlled by multiple pathways including Ca2+ release from intracellular Ca2+ stores and Ca2+ entry through Ca2+ channels.
Sss1, however, inhibits the target gene by multiple pathways, including de novo DNA methylation, H3K27 and H3K9 hypermethylation, and the recruitment of Heterochromatin Protein 1 (HP1a).
The breakdown of B-cell tolerance is probably a defining and early event in the disease process and may occur by multiple pathways, including alterations in factors that affect B-cell activation thresholds, B-cell longevity, and apoptotic cell processing.
Taken together, in addition to lowering IOP, BMD may prevent glaucomatous retinal degeneration by stimulating multiple pathways including glia neuron interactions.
These results suggest that, in addition to lowering IOP, BMD prevents glaucomatous retinal degeneration by stimulating multiple pathways including glia neuron interactions.
In addition to regulating its gene expression, Skp2 is regulated by protein stability through multiple pathways, including phosphorylation, subcellular localization, and proteasomal degradation.
39 Moreover, it has been shown that this high glucose-induced COX-2 mRNA expression was implicated by the involvement of multiple pathways, including the p38 MAPK, PKC, and NF-κB.
The inhibition of RAS by ACEI or ARB reportedly influences multiple pathways including angiogenesis, proliferation, and apoptosis, and can be a safe and inexpensive strategy against pancreatic cancer, but a prospective study is warranted to evaluate antitumour effects by the inhibition of RAS.
