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At the cellular level, inflammatory cytokines such as IL-1β are regulated by multiple molecular pathways including the mitogen-activated protein kinase (MAPK) pathway.
The biological and clinical behaviour of CRC is affected by multiple molecular pathways controlling cellular processes like differentiation, migration, replication, DNA repair, proliferation and apoptosis (Sancho et al, 2004); one particularly well-studied pathway is the Wnt pathway (de Lau et al, 2007).
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On the whole, SIRT1 can be regarded as a crucial anti-aging protein which mediates its widespread effects in preventing premature senescence and accelerated aging by regulating multiple molecular pathways.
Classical miRNAs are master regulators of human cancer metastasis, by targeting multiple molecular pathways involved in each step of this complex phenomenon [ 144 ].
32, 33 Besides, as a microRNA molecule targets to a set of coding genes, rather than a single one, therapies based on microRNA interference could be more potent in cancer treatment by targeting multiple molecular pathways.
These results provide powerful evidence for the chemopreventive efficacy of CH against chemically induced renal carcinogenesis possibly by modulation of multiple molecular pathways.
The stimulation of adult hippocampal neurogenesis by antidepressants has been associated with multiple molecular pathways, but the potential influence exerted by other brain areas has received much less attention.
The present review summarizes recent findings in meprin research in health and disease and describes the multiple molecular pathways mediated by meprin activity.
These studies have also shed light on multiple molecular pathways modulated by these fatty acids in cancer cells and implicated in the regulation of several cell processes involved in cancer development and progression, such as cell proliferation, survival, differentiation, invasion, and angiogenesis.
UV radiation from the sun impacts skin health adversely through complex, multiple molecular pathways.
Our findings suggest that multiple molecular pathways might work in tandem to protect the nigrostriatal dopaminergic pathway against the deleterious effects of the toxic psychostimulant.
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