The RS domains of SR proteins are conserved, and the serine residues within these domains are targets of phosphorylation by multiple kinases, including SRPK1 [30] and SRPK2 [31], Clk/Sty [32], and DNA topoisomerase I [33].
In A compartment cells far from the A/P compartment border which receive no Hh signal, full-length Ci (Ci-155) is phosphorylated by multiple kinases including PKA, which leads to generate a C-terminally truncated form [18] [24].
Following on from this, we remark that several other TFs are indeed, like FOXO, regulated by multiple PTMs, including the tumour suppressor p53 (UNIPROT accession P04637 for the human protein), which can undergo modifications including phosphorylation (by multiple kinases including ATM/ATR), acetylation, methylation and ubiquitylation at least 17 sites [133].
The phosphorylation of p27 on T198 can be directed by multiple kinases including AMPK [ 31], Akt [ 32], and Rsk1 [ 33].
Entry and progression of mitosis is tightly regulated by multiple kinases including Aurora-A (Marumoto et al., 2005).
The phosphatidylinositide lipids produced by PI3K can stimulate multiple kinases, including protein kinase B/Akt, which is a central downstream mediator of anti-apoptotic signals transmitted by PI3K (Datta et al, 1999).
Multiple kinases, including PKA, cyclic GMP-dependent protein kinase (PKG), and protein kinase C (PKC), can regulate BK channel currents.
Sunitinib is an oral tyrosine kinase inhibitor that targets multiple kinases, including the vascular endothelial growth factor receptors (VEGFR-1, VEGFR-2 and VEGFR-3), PDGFRs, KIT, FLT3 and the receptor encoded by the RET proto-oncogene.
In vitro studies of kinase-reduced mutants such as p.G466V, p.G466E and p.G596R, have also shown that activation of the CRAF/MEK/ERK cascade can be inhibited by MEK inhibitors or sorafenib, an inhibitor for multiple kinase including CRAF.
In addition to the abovementioned GSK-3β, C/EBPβ is also targeted by multiple protein kinases including protein kinase A, calmodulin-dependent protein kinase, Erk-1/2, ribosomal protein S6 kinase, and CDK2 [44].
