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The likelihood of infectious disease occurrence is typically influenced by multiple interacting factors.
Inhibition of β-catenin phosphorylation by Wnt signalling leads to the accumulation of β-catenin which forms a bipartite complex with members of the TCF/LEF transcription factor family and activates the transcription of target genes, a process which is regulated by multiple interacting factors [ 8].
Despite the political pressures on many donor agencies to demonstrate 'value for investment' in the short term and to attribute specific health outcomes to research programs, it is hard to do so when dealing with complex socio-ecological systems that are dynamic in nature and are influenced by multiple interacting factors.
Health inequity is caused by multiple, interacting factors described by the WHO Commission on Social Determinants of Health (CSDH) as 1) the socioeconomic and political context, 2) social position, 3) material circumstances and 4) the health system [ 2].
However, explanatory models propose that CFS/ME represents a state of physiological dysregulation in which the maintenance of established symptoms may be influenced by multiple interacting factors, such as patient symptom preoccupation, beliefs, and behaviors in response to the condition (Deary, Chalder, & Sharpe, 2007; Surawy, Hackmann, Hawton, & Sharpe, 1995).
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Factorial analysis is an efficient tool to accomplish this type of optimization involving multiple interacting factors.
If the conditions that cause war are complex, with multiple interacting factors (including chance), then outcomes cannot easily be predicted on the basis of single factors.
It is most likely that multiple interacting factors play roles at different time points.
A recent review has considered the multiple interacting factors that may play a role in this association [ 43].
Parenting encompasses a complex and multi-dimensional set of behaviours influenced by multiple interacting, intra- and inter-personal factors and environments [ 1, 2], and it is well established that the parenting practices to which children are exposed can impact on their development, future health and social functioning.
However, long-term survival after HCT is likely influenced not by a single mismatch but by multiple interacting mismatches as well as by patient and donor clinical characteristics and biological factors.
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