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However, several of the enzymes are encoded by multiple genes that are regulated differently, adding unexpected genetic complexity.
The current study builds upon our previous work and reveals that mosquito species-specificity of CHIKV, and potentially of other important human and animal pathogens, for example VEEV, can be influenced by multiple genes that can act synergistically.
We also included two representatives of early diverging angiosperm lineages as outgroup species, Amborella trichopoda and Magnolia grandiflora, and we added 4 other species, each represented by multiple genes, that were included in clades whose members did not have overlapping sequences (see Appendix S1).
In plants, cell shape patterning and growth are regulated by multiple genes that are mediated by actin and microtubule cytoskeleton-dependent trafficking pathways [ 1- 3].
Sugar accumulation in fruit is a complex quantitative trait, affected by environmental conditions and dependent on many interconnected physiological and metabolic processes, and controlled by multiple genes that interact with the environment and crop management.
Schizophrenia is a highly heterogeneous disease effected by multiple genes that generally belong to different hypothesis for the etiology of this disorder [ 24], such as the dopamine D2 receptor gene, a key member of dopamine hypothesis for schizophrenia, whose polymorphisms are associated with schizophrenia [ 25].
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This subgroup was marked by mutations of multiple genes that exhibit a mutually exclusive pattern in this cohort (Fig. 4 and in Additional file 1: Figure S4).
Complex biological processes, such as the locust phase transition which involves changes in behavior, body color, physiology and even reproductivity, are not likely to be controlled by a single gene but multiple genes that interact in molecular networks.
Genomic islands (GIs) are mobile genetic elements acquired by horizontal transfer, which carry multiple genes that are typically involved in pathogenesis or symbiosis.
Preliminary studies to find targets of miR-200a have identified multiple genes that are targeted by this microRNA (Fig. 4A), and represent potential mediators of the miR-200a-induced effects observed in culture.
We investigated whether there were genomic regions containing multiple genes that were regulated by TSA.
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