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It is a complex genetic disorder, influenced by multiple genes of small effect.
Essential hypertension (EH) and cardiovascular disease are common, multifactorial disorders likely to be influenced by multiple genes of modest effect.
Instead, most now agree that such illnesses are most likely "oligogenic," mediated not by a single gene, but by multiple genes of smaller effect acting in combination with one another and the environment.
Genome-wide association studies and admixture mapping are approaches that remain to be applied to TB, and it is not clear, as is the case with other complex diseases, how much of the heritability of the TB susceptibility phenotype will be determined by multiple genes of small effect versus rare variants with disproportionately large effects.
Both ADHD and quantitative measures of hyperactivity are heritable, and influenced by multiple genes of small effect.
The majority of traits that show variation based on genetic influences are affected by multiple genes of small effect as well as by environment.
Similar(44)
Identification of sequences shared by multiple genes to form a library of nucleotide- and peptide-based tools capable of simultaneously targeting key pathways.
If offspring from hybrid (between population) crosses were intermediate to offspring from pure-bred (within population) crosses in juvenile development time, then we would conclude development time is a quantitative trait (controlled by multiple genes, each of small effect).
The balance between cellular proliferation and cell death is regulated by multiple genes or families of genes through the cell cycle.
If the trait was controlled by multiple genes, a range of intermediate phenotypes between both parental phenotypes might be expected, but that was not the case.
However, whereas almond toxicity is controlled by one gene such that mutant plants provide offspring that are also non-toxic, toxicity in oak is determined by multiple genes, meaning that offspring of non-poisonous oaks are rarely non-poisonous themselves.
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