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Conclusion: The rapid effects of BPA on female rat cardiac myocytes are characterized by nonmonotonic dose responses as measured by multiple end points.
Results: The rapid effects of BPA in cardiac myocytes, as measured by multiple end points, including development of arrhythmic activities, myocyte mechanics, and Ca2+ transient, were characterized by nonmonotonic dose responses.
The cardiac actions of BPS, as measured by multiple end points, are similar to those previously reported for BPA; also similar are the cellular and molecular mechanisms underlying the effects of the two chemicals.
The rapid effects of BPA on female rat cardiac myocytes were characterized by nonmonotonic dose responses, as measured by multiple end points; the cellular mechanism of BPA's nonmonotonicity involves monotonic and opposing effects on multiple Ca2+ handling processes, all mediated by ERβ signaling.
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Multiplicity of the statistical testing was indicated by multiple markers and multiple end points; the numbers of markers in each sample type are shown in table 2. Six baseline disease characteristics and one clinical response end point were used.
Multicriteria decision analysis (MCDA) can help overcome this by using stakeholder preferences to combine multiple end points into an overall value estimate.
Using standard approaches, as recommended by the U.S. EPA (2012a), we evaluated multiple end points and identified features of animal study methods that may influence their utility for BMD modeling.
The brief article, co-authored by nutrition guru Dr. JoAnn Manson, cites multiple large clinical trials studying multiple nutritional supplements' effects on multiple end points.
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Multiple end points were assessed postinfection.
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