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Orlikow was treated by renowned psychiatrist Doctor Ewen Cameron, whose controversial "de-patterning" treatment prolonged, drug-induced sleep comas, followed by multiple doses of electroshock therapy turned out to be a part of Project MKUltra.
Orlikow was treated by renowned psychiatrist Dr Ewen Cameron, whose controversial "de-patterning" treatment prolonged, drug-induced sleep comas, followed by multiple doses of electroshock therapy turned out to be a part of Project MKUltra.
However, imatinib exposure (Cmax, AUC) was reduced by multiple doses of genistein administration.
Experimental diabetes was induced by multiple doses of STZ [150 mg (kg−1 body weight)] in a mouse model.
Only a single dose of human antibody was given to prevent any potential immune response elicited by multiple doses of a foreign protein.
We then determined whether Nrf2 activation by multiple doses of oltipraz administration rescued the kidney from cisplatin toxicity at day 5 (at which serum creatinine level sufficiently increased).
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A common aim in a clinical setting then is to maintain the dose of a drug within a therapeutic window defined by the limits of the MED and MTD which is often achieved by applying multiple doses of the drug at intermittent time points (Fig. 1b).
By 2008, multiple doses of rotavirus, hepatitis A, pneumococcal, varicella, and meningococcal vaccines, as well as a yearly influenza vaccine for all children 6 months to 18 years of age, had been added to the vaccine schedule.
Further studies to clarify this question should attempt to reduce variability in IDV plasma concentrations, either by giving multiple doses of IDV at shorter intervals to maintain plasma IDV concentrations constant while insulin sensitivity is assessed, or using an IDV regimen boosted with ritonavir.
Hepatosplenomegaly was prolonged by multiple doses.
Intratympanic L-N-acetylcysteine was well tolerated by patients receiving multiple doses of cisplatin as part of their oncologic treatment.
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