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Changes in between the quadrants were analyzed using the Friedman test followed by multiple comparisons using Wilcoxon signed-rank non-parametric test with Bonferroni correction.

Differences in both ratios among locations were tested with non-parametric Kruskal-Wallis tests followed by multiple comparisons using the non-parameteric Dunn's test, which allows for unequal sample sizes [38].

Significance was assessed by multiple comparisons using the Student's t -test and a Bonferonni correction.

Data with heterogeneous variances were analyzed using Kruskal Wallis analysis of variance followed by multiple comparisons using Dunnett's test [ 12].

Differences between groups were determined by multiple comparisons using contrasts, and the Sidak method for P-value adjustment.

Significance was assessed by multiple comparisons using the Student's t -test and a Bonferonni correction (*p < 0.001).

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Differentially expressed genes among the 6 organs were identified from SAM test, followed by multiple comparison using Tukey's HSD; and (iii) we ranked the genes by organ specificity index (OSI), higher OSI, more specific a gene in one or two organs.

Treatment effects were determined by one way analysis of variance (ANOVA) and significant difference between the groups was determined by pairwise multiple comparisons using Dunn's test.

All the data were analyzed statistically by One-way ANOVA followed by Tukey's multiple comparisons using SPSS software student's version-16.

Data were analyzed by one-way ANOVA followed by Dunnet's multiple comparisons using GraphPad Prism 4.0, statistics software.

Group data were analyzed by analysis of variance followed by post hoc multiple comparisons using Tukey's honestly significant difference test (KaleidaGraph; Synergy Software, Reading, PA).

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