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The generation of T cell immunity is regulated by multiple cellular and molecular events.
Cell death is a complex phenomenon that is independently or coordinately regulated by multiple cellular and molecular mechanisms.
The regulation of viral gene expression is complex and is controlled by multiple cellular and viral transcription factors.
Cyclooxygenase-2 inhibition significantly inhibits CRC growth and invasion/migration, and retards the formation of liver metastasis by multiple cellular and molecular mechanisms.
Cyclooxygenase inhibition suppresses tumour cell growth and invasion, and retards the formation of liver metastasis in a mouse CRC model by multiple cellular and molecular mechanisms.
Therefore, the improvement in arterial properties shown after n-3 PUFA supplementation is multifactorial and involves both passive and active mechanisms of arterial hemodynamics, mediated by multiple cellular and molecular pathways and influenced by some major cardiovascular risk factors (hypertension, blood lipids, and autonomic balance).
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These effects are mediated in the osteoblastic cells by multiple cellular pathways and involve the induction of several target genes as insulin-like growth factor-I (IGF-I), Runx2, amphiregulin 1, alpha hydroxylase, transforming growth factor (TGF -beta, RANKL, or mononuclear phagocyTGF -beta-stimulating factoRANKLCSF) (Roren 2003).
Here we reviewed the emerging evidence that FXR may act as a protective factor in ALD by regulating multiple cellular and molecular pathways.
It is believed that formation of non-B DNA conformations (inherently of high energy states) is supported by duplex destabilization resulting from negative supercoiling induced by multiple cellular processes including transcription, replication and also protein binding.
The recruitment, activation, and effector function of Th17 cells and neutrophils are driven by a network of cytokines and chemokines secreted by multiple cellular sources.
The toxicity of O2 is due to its intermediate species, known as reactive oxygen species (ROS), which are normally scavenged by multiple cellular antioxidant systems present in both prokaryotic cells and eukaryotic cells.
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