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Previous studies conducted in industrialized countries have provided insight into nationwide epidemiology supported by molecular typing data (11, 28 – 32 ), although these studies have not been set up to direct the source tracing.
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Furthermore, by incorporating molecular typing data with epidemiological data, CDI clusters can be further examined to better identify potential outbreaks, prevent the misclassification of cases as outbreak or non-outbreak, and elucidate transmission events.
Multilocus sequence typing (MLST) produces unambiguous molecular typing data [11], [12].
A good example is provided by the molecular epidemiological databases that have been developed for a number of bacterial and fungal pathogens, where communities of researchers and public health laboratories submit data on strains of individual pathogens, including basic epidemiological information and molecular typing data (for example, http://www.mlst.net) [1], [2].
CM provided molecular typing data; AC supported epidemiological and statistical results.
MRSA molecular typing data were available for matching for 46.7 % (2248/4818) of incident IPC cases.
In addition, molecular typing data from these familial MRSA transmissions is limited [ 19, 21].
The entire data set of patients and controls is composed by molecular typing for both HLA class I and II genes.
Clonal relationships were determined by molecular typing.
The diagnoses were confirmed by molecular typing.
By integrating epidemiologic, microbiological, and molecular strain typing data with in vitro competitive growth experiments, we provide evidence for an initial mixed infection with a drug-sensitive strain and an undetected drug-resistant strain that outgrew the sensitive strain under the selection pressure of first-line chemotherapy.
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