Taken together, these data suggest that RNF20 plays a critical role in the regulation of hepatic lipid metabolism by modulating the protein stability and transcriptional activity of SREBP1c during hormonal changes.
FWD-1 is the E3 ubiquitin ligase responsible for FRQ ubiquitination, and the COP9 signalosome regulates FRQ stability by modulating the activity and stability of the SCFFWD-1 complex that is critical for FRQ degradation.
Recent research also suggests that this might be mediated by SUMOylation, a process that plays a part in modulating the stability of the FOXM1 protein [75].
This gene is involved in lipid desaturation, suggesting that it may act by modulating the plasma membrane stability under alcoholic stress.
It is involved in many pathways such as cell cycle control, DNA repair and apoptotic response to stress by modulating the activity and stability of critical tumour-suppressor proteins such as p53 [ 54].
The incorporation of Ch can increase stability by modulating the fluidity of the lipid bilayer preventing crystallization of the phospholipid acyl chains and providing steric hindrance to their movement.
The dendritic localisation of CK1δ might indicate a role of CK1δ in regulating neurite outgrowth, dendritic plasticity and stability by modulating the dynamic of both, the microtubule and the actin network.
6,7,55 In addition, an increasing number of small organic molecules can mimic the activity of pharmacological chaperones by modulating the folding machinery or protein stability (chemical chaperones).
Moreover, this promoting effect of IL-17 was found to be exerted through enhancing mRNA stability by modulating the protein level of ARE/poly(U -binding/degradation factor 1 (AU -binding/degradationtor that promotes mRNA decay.
