Sentence examples for by modulating the splicing from inspiring English sources

Thus, concerning the genome of these different species, alternative splicing of the actin-binding domain of cortactin seems to be facilitated during evolution by modulating the splicing machinery by a GT-to-GC transition to create cortactin related variants that influences cellular properties [ 14].

Besides, gli-similar 3 (GLIS3) may favor β-cell apoptosis by modulating the alternative splicing of the proapoptotic BH3-only protein Bim and exacerbating the formation of the most proapoptotic variant BimS [ 87, 88].

Other reports have also identified ncRNAs at nuclear speckles, where these molecules could regulate alternative splicing by modulating the activity of splicing regulatory proteins [ 70].

Therefore it is likely that in modulating chromatin structure, arsenic directly affects splicing patterns and/or indirectly by modulating the expression of splicing factors (Additional file 12: Table S6).

Taken together, these results indicate that delivery of antisense U7 snRNAs by Adenovirus type 5-derived vectors has a similar efficacy in modulating the splicing pattern of SMN2 minigenes as transient transfection of antisense U7 snRNA expressing cDNAs.

Where some splice mutations result in non-functional or deleterious protein isoforms, AOs could be targeted to mutated splice motifs, thereby modulating the splicing process and restoring the expression of functional protein.

Exon bridging interactions may occur less efficiently as a result of weak binding of splice factors at the acceptor site, thus modulating the splicing efficiency.

These findings highlight the role of PAR and PARP-1 in regulating alternative splicing by modulating the binding of hnRNPs to their target RNAs.

These data suggest that H2BK123ub1 facilitates cross talk between chromatin and pre-mRNA splicing by modulating the distribution of intronic and exonic histone modifications.

The alternative splicing of the flanking EGF and SCR modules could also have a regulatory function by modulating the C-type lectin-mediated interactions [ 8].

These data suggest that by modulating the distribution of intronic and exonic histone modifications, H2BK123ub1 facilitates cross talk between chromatin and pre-mRNA splicing.