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Diet could re-shape the community structure of gut microbiota and influence its function by modulating the production of metabolites.
Similar to G6PD, 6PGD may also regulate cellular reductive biosynthesis and cell proliferation by modulating the production of NADPH and R5P.
The data presented here show that Pin1 influences the type I immune response by modulating the production of proinflammatory, T cell cytokines including IFN-γ and IL-2.
Statins may improve endothelial function by modulating the production of reactive oxygen species [ 7].
Nondigestible carbohydrates/prebiotics have been shown to reduce food intake by modulating the production of gastrointestinal peptides [ 46, 47].
However another possible explanation may be that SrRan could positively influence defect vascularization by modulating the production of vascular endothelial growth factor (VEGF) from osteoblasts.
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However, β2 activation as well as β1 blockade seems to downregulate proinflammatory response by modulating the cytokine production profile.
We stress that in our simulations we keep constant the average concentration of the autoinducer by modulating the effective production rate (see Eq. (14)).
These and other studies (reviewed in [ 72]) indicate that one of the major roles of FGF signaling in ECs might be to orchestrate a complex crosstalk between ECs and pericytes by not only modulating the production of other growth factors (amongst which PDGF and VEGF appear pivotal) but also the responsiveness of the cells to these factors.
This expression correlation may be explained by a bi-directional cross-talk between the two proteins; where by HER2 can regulate the expression of cPLA2 α which in turn functions by modulating the transcription of HER2 through the production of PGE2 (Benoit et al, 2004; Caiazza et al, 2010).
AMPK [ 35] signaling also regulated adiponectin production by modulating the expression of its receptors and itself.
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