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These findings confirm the immunoblotting data and further show that SHP2 suppresses ligand-induced EGFR degradation by modulating the process of sorting.
Taverna et al. showed that exosomes released from CML cells directly affect ECs by modulating the process of neovascularization, both in vitro and in vivo, by inducing in ECs the release of proangiogenic cytokines, such as Interleukin-8 [ 52].
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M2 macrophages are associated with the healing process by modulating the inflammatory process and by secreting factors like CCL18.
By modulating the extraction process, it became possible to obtain different modified madder-based products, e.g. garancine (1828), enriched in alizarin and purpurin, and Kopp's purpurin (also known in France as "purpurine commerciale"), enriched in both purpurin and pseudopurpurin [4].
The TGF superfamily contains more than 40 proteins involved in tissue homoeostasis and determination of cell fate by modulating the cellular process from membrane to nucleus [ 50].
In view of the inflammatory nature of OA, it is believed that laser treatment can play a beneficial effect by modulating the inflammatory process.
The authors analyzed several inflammatory mediators, including IL-1β and IL-6, and concluded that LLLT acts by modulating the inflammatory process, and possibly stimulates the production of anti-inflammatory mediators [ 23].
Heuze et al. have shown that Asb-2 may regulate haematopoietic cell differentiation by modulating the cell-spreading process [ 4].
Osteoblasts can regulate bone metabolism by modulating the bone resorption process, directly via the production of receptor activator of nuclear factor κβ ligand (RANKL) and negatively via the secretion of its decoy receptor Opg [ 45, 46].
There is substantial interest in developing small molecules that can prevent protein aggregation for a variety of protein misfolding disorders by modulating the kinetics of the process.
Auger electron spectroscopy confirmed that Cr2N and CrN bulk film stoichiometry was achievable by modulating the argon to nitrogen process gas ratio during deposition.
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