Sentence examples for by modulating the phosphorylation from inspiring English sources

Collectively, these results demonstrate that dexamethasone induces osteogenesis, at least in part, by modulating the phosphorylation state of a negative-regulatory serine residue (Ser125) on Runx2.

We may also conclude that, by modulating the phosphorylation level of laminin, TNAP impacts on the interaction between PrPC and laminin.

These observations suggested that the increased levels of the IFI16 protein under glucose restriction modulate the p53-mediated cell survival by modulating the phosphorylation of p53 and the expression of its target genes.

Besides, we provide evidence that the PrPC-interacting protein laminin is a substrate for TNAP in 1C11-derived neuronal cells, and that, by modulating the phosphorylation level of laminin, TNAP impacts on the interaction between PrP and laminin.

A complex interplay between protein tyrosine kinases and phosphoprotein tyrosine phosphatases regulates ion channels by modulating the phosphorylation state of specific tyrosine residues in channel proteins (37).

It is reported that RetS and LadS interact with the GacS/ GacA system by modulating the phosphorylation state of GacS, which consequently inhibits and promotes, respectively, the phosphorylation of GacA [ 82, 83].

AKT/PKB (Protein Kinase B) can enhance tau phosphorylation directly [24] or indirectly by modulating the inhibitory phosphorylation of GSK-3β at Ser9 [25].

mTOR may also indirectly influence the phosphorylation condition of 4E-BP1 by modulating the activity of PP2A (Protein Phosphatase-2A).

The susceptibilities of several caspase substrates were previously shown to be modulated by phosphorylation, as were the activities of caspases-9 and 3 themselves [ 52, 53], suggesting that kinase/phosphatase signalling could be crucial for both direct caspase regulation as well as for restricting or specifying substrate availabilities by modulating the cellular phosphoproteome.

ISRIB does not elicit this phenotype by modulating this phosphorylation site.

In addition, DARRP-32 is a known target of calcineurin and CsA treatment stimulates the function of DARPP-32 by modulating its phosphorylation status [ 26, 41].