Sentence examples for by modulating the local from inspiring English sources

a | Mechanisms active in the primary tumour restrain antitumour immune responses by modulating the local microenvironment and creating an immunosuppressive milieu.

It is shown that this loss can be compensated by modulating the local bed height via a moderate inclination of the bed support.

Glycine transporter 1 (GlyT1) inhibitors have emerged as potential treatments for schizophrenia due to their potentiation of NMDA receptor activity by modulating the local concentrations of the NMDA co-agonist glycine.

However, IVIG has only a relatively limited point of action by modulating the local immunity [ 16].

mRNA secondary structures influence a number of cotranslational processes by modulating the local translation rate.

Busulfan conditioning regimen was recently shown to allow efficient turnover of microglia with donor-derived elements by modulating the local brain environment, likely by creating "space" for the engraftment through depletion of endogenous microglia [ 19, 88].

Post-translational modifications of the amino-termini of nucleosomal histones are also known to regulate transcription [ 8, 9] by either modulating the local chromatin structure to control TF accessibility [ 4] or directly recruiting chromatin remodellers and other related enzymes [ 10].

By modulating the effective local concentration of proteins rather than their absolute concentration, supramolecular protein recruitment provides an efficient mechanism to gain spatiotemporal control over protein activity in the highly crowded environment of the cytoplasm5,6.

A gradient into the Ge coverage has been thus induced by the diffusion process, strongly modulating the local density of Ge atoms upon the distance from the source stripe.

Given that ASCs produce bFGF but not GDNF, these findings indicated that ASCs may promote neuroprotection either directly and/or by modulating the response of local glial cells toward a neuroprotective phenotype [ 40].

This could be achieved by two independent mechanisms: firstly by strengthening the cell cytoskeleton and, therefore, the physical resistance of the epithelial layer and secondly by modulating the immune environment at local mucosal level towards a "prestimulated" innate immune response by recruiting immune cells.