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This transformation can be implemented in the laboratory, for instance, by artificially modulating the length of the trap [30], or equivalently by modulating the interaction strength [8, 9].
Considered collectively, valproate may regulate the UPR by modulating the interaction between GRP94 and WFS1.
The conformation of the central β-rich region may play an important role in RNA binding by modulating the interaction and presumptive binding surface between the two main domains, which could convey evolutionary advantages and virus specificity.
Since SLPI was able to disrupt the association between PLSCR1 and CD4, our data suggest that SLPI inhibits HIV-1 infection by modulating the interaction of the CD4 receptor with PLSCRs.
Although it seems likely that the effect of sodium butyrate on LP BER is mediated at least in part by increased acetylation of WRN, it remains possible that the effect of sodium butyrate is mediated by modulating the interaction between WRN and other proteins involved in BER.
DNA methylation can regulate gene expression by modulating the interaction between DNA and proteins or protein complexes.
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IGFBPs bind IGFs with similar or higher affinities than IGF-receptors, regulating their biological activities by acting as a reservoir of IGFs in the circulation and by modulating the interactions between IGFs and their receptors at cellular level.
The findings described here form a milestone in discovering novel inhibitors for the NER pathway aiming at improving the efficacy of current platinum-based therapy, by modulating the XPA ERCC1 interaction.
Both these pathways activate SIRT1 by modulating the SIRT1 DBC1 interaction.
Although the AUF1 PABP1 interaction does not directly affect PABP1 poly(A) binding, it was proposed that it causes PABP1 eviction from the poly(A) tail, possibly by modulating the PABP1 eIF4G interaction, leading to deadenylation.
Among bacterial infections, a role for miR has been suggested in M. tuberculosis infections by modulating the monocytes/macrophages interactions with the bacterium or regulating the expression of resistance gene or virulence factors.
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