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Kunnumakkara, A. B. et al. Gamma-tocotrienol inhibits pancreatic tumors and sensitizes them to gemcitabine treatment by modulating the inflammatory microenvironment.
In addition, but mainly based on preclinical studies, volume resuscitation with hypertonic fluids may exert intrinsic beneficial effects by modulating the inflammatory response and apoptosis in trauma and sepsis; these effects however have not yet been convincingly shown in clinical studies [5, 6].
In another study, histatins were presented to supporting re-epithelialization and wound healing, possibly by modulating the inflammatory response.
hMSCs enhanced functional recovery by modulating the inflammatory reaction during Wallerian degeneration and by stimulating the production of growth factors.
M2 macrophages are associated with the healing process by modulating the inflammatory process and by secreting factors like CCL18.
By modulating the inflammatory response and limiting fibrosis, IGF-1 maintains the balance between inflammation and connective tissue remodelling [ 141].
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What is clear is that signals from inflammatory cells at the wound site directly influence these fibroblast behaviors, and thus by modulating the wound inflammatory response, it is possible to dramatically modulate the scarring phenotype.
In another study, UC-MSCs could attenuate the progression of FSGS by improving kidney fibrosis and modulating the inflammatory response [ 40].
By upregulating the regeneration/differentiation markers, modulating the inflammatory response, and attenuating fibrogenesis, the stimulation of AVP-dependent pathways creates a favourable environment for efficient and sustained muscle regeneration and repair even in the presence of elevated levels of TNF.
In recent years, it has been reported that UC-MSCs could meliorate clinical parameters and histology by improving kidney fibrosis and modulating the inflammatory response (including inhibiting lymphocytes, inducing polarization of Th2 cytokines, and inhibiting proinflammatory cytokines) in experimental lupus nephritis [ 27, 28].
Nevertheless, modulating the inflammatory response by changing cell type polarization, cell number, or degree of activity can instead promote regeneration and reduce pathology, thus improving functional outcome 1, 14, 28, 31.
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