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In mammals, base exchanges from adenosine-to-inosine (A>I) represent the most common RNA editing mechanism, which influences neurotransmission by modulating the functional properties of glutamate receptors [44], serotonin receptors [43] and potassium channels [42].
In summary, results from our study indicate that PSLs will affect neuroinflammation by modulating the functional properties of macrophages.
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Comparative transcriptomics analysis suggested that the AZFP in the mutant exerted beneficial effect by modulating the expression of multiple functional genes.
Although these cations do not play a direct role in the cleavage mechanism, they may contribute either through electrostatic stabilization or by modulating the p Ka of functional residues.
These diverse modifications are read out by effector protein complexes, which ultimately determine their functional outcome by modulating the activity state of underlying genes.
hMSCs enhanced functional recovery by modulating the inflammatory reaction during Wallerian degeneration and by stimulating the production of growth factors.
Therefore, IGF‐1 deficiency is unlikely to contribute to impaired functional hyperemia by modulating the neural activity evoked by whisker stimulation.
Since glutamine is more hydrophilic than arginine, the amino acid substitution may affect the relative position of the two functional domains by modulating the flexibility of the linker connecting them [ 57].
Our data suggest that microstructure of the posterior callosal third affects functional hemispheric asymmetries by modulating the timing of interhemispheric interactions.
The functional validation is mostly assessed by modulating the expression levels of cellular proteins (overexpression, knockout or knockdown).
It is possible to assume that the realization of different patterns on the same surface, in terms of geometry, dimension and spatial organization, can lead to a new type of functional structured surfaces, simply by modulating the entity of the three properties.
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CEO of Professional Science Editing for Scientists @ prosciediting.com