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Genetic factors most likely contribute to this variability by modulating the effects of tDCS.
Genetic factors could act by predisposing to conventional risk factors, by modulating the effects of those risk factors on the target organs or, conversely, by a direct independent effect on stroke risk and on infarct evolution.
Normally, DPP IV and NEP act as regulatory proteins in cancer progression and development by modulating the effects of biologically active peptides, but eventually, they also can act as proteinases which execute extracellular matrix degradation [ 6, 7].
Trastuzumab can induce normalization and regression of the vasculature in an experimental human breast tumor which overexpresses HER2 in mice, by modulating the effects of different pro- and anti-angiogenic factors [ 9].
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11 It is an opioid system modulator with a distinct μ, δ and κ receptor profile, and by modulating the effect of alcohol on the corticomesolimbic system it is thought to reduce the reinforcing effects of alcohol, thereby helping patients to reduce their level of consumption.
We suggest that CRP delays the onset of autoimmune disease by modulating the effect of immune complexes on inflammatory cells.
In line with this, previous reports described a compensatory effect of EDN3 by negatively modulating the effects transduced by EDN1 [ 17] and demonstrated that downregulation of EDN3 is associated with upregulation of EDN1 in human tissues [ 18].
On the other hand, many other reported effects of estrogen in hippocampal area CA1 might confer increased sensitivity to ischemia, either by modulating the excitatory effects of glutamate or by modifying the inhibitory effects of GABA.
It has been stressed that pain catastrophizing may also worsen the experience of pain through physiological and neural pathways by enhancing it via differential patterns of brain activation [41] and by modulating the analgesic effects of medications affecting the endogenous opioid system [42, 43].
Phase is a "variational property" meaning that it does not contribute directly to organismal replication rates within one generation, but indirectly, by modulating the phenotypic effects of point mutations on descendant sequence variability.
Activated platelets release from alpha granules various proteins, e.g. PF4, which has high affinity for glycosaminoglycans and exerts pleiotropic effects in hemostasis and thrombosis by, among others, modulating the effects of heparin-like molecules [ 36].
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