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The role of phytochemicals in the inhibition of cancer and inflammation has also been extensively studied and it is now clear that these exert their action by modulating phase I and phase II enzymes and by modulating the cell signaling pathways involved in inflammation (Issa et al 2006).
CXCR2 is well known for playing critical roles in cancer progression by modulating the cell cycle, apoptosis, and angiogenesis [ 37, 38].
Since we demonstrated that CSC-pretreated C. albicans produced more chitin, this can be considered as a protective pathway used by Candida to overcome the damaging effect of CSC by modulating the cell walls.
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Heuze et al. have shown that Asb-2 may regulate haematopoietic cell differentiation by modulating the cell-spreading process [ 4].
Our results indicated that shikonin might cause G1-phase arrest in A431 cells by modulating the cell-cycle regulatory proteins.
At the cellular level, GS3 controls grain size largely by modulating the longitudinal cell number in grain glumes.
Thus, sortase plays a crucial role in the surface-related properties by modulating the bacterial cell surface [ 31].
It is conceivable to alter the progression of RA by modulating the T-cell responses at a very early stage of RA [ 15].
NF-κB controls the cell-cycle progression by modulating the action of cell-cycle regulatory proteins.
In this study, we found that knocking down CDK4 expression elevated the expression of tumor suppressor let-7c by modulating the G1/S transition cell signaling pathway, which in turn suppressed cell growth by through the p15/p16/CDK4/E2F1 pathway.
Thus, progression of the cell cycle can be regulated by modulating the quantities of cell-cycle regulators through ubiquitination by the SCF complex [ 1].
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