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Insulin could affect IGF-1 signalling further by modulating the availability of IGFBPs.
For instance, circadian rhythms of tumor-necrosis factor-α (TNF-α) receptors have been linked with central thermoregulation, especially during immune activation from endotoxin, by modulating the availability of free TNF-α [ 33].
By modulating the availability of β-catenin, which binds to the intracellular domain of E-cadherin and helps to connect AJs with the actin cytoskeleton, E-cadherin-based AJs are involved in cell signaling and transcriptional regulation.
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Anti-ecdysteroidal compounds may act by reducing ecdysteroids titers, competing antagonistically for the ecdysteroids receptor, or modulating the availability or activity of downstream contributors to the signaling cascade.
The susceptibilities of several caspase substrates were previously shown to be modulated by phosphorylation, as were the activities of caspases-9 and 3 themselves [ 52, 53], suggesting that kinase/phosphatase signalling could be crucial for both direct caspase regulation as well as for restricting or specifying substrate availabilities by modulating the cellular phosphoproteome.
These studies demonstrate that oxysterols regulate cholesterol accessibility, and thus the availability of cholesterol to be sensed and transported throughout the cell, by modulating the membrane environment.
By modulating the sound, that pocket can be moved around, changing the position of the bead.
The system works by modulating the LED lighting in your home or office.
By modulating the flux through the loop,the cavity frequency is modulated.
This wobbled the beam by modulating the deflection lens current.
Sensing of low phosphate availability also triggers long distance signals to systemic tissues that activate phosphate homeostasis mechanisms via increased phosphate transport, recovery, and recycling by modulating the expressions of high-affinity transporters, secreted phosphatases, and phospholipid catabolism enzymes.
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