Furthermore, Sema3E/PlexinD1 binding mediates the disassembly of actin filaments by PAK activation by modulating the activity of small GTPases in several cell types (see ref. 36 for review).
Through these interactions, Src controls cell growth and survival by modulating the activity of such intracellular effectors as PI3K/Akt and signal transducer and activator of transcription 3 (STAT3) [ 11].
This compound might interfere with cell migration by modulating the activity of different upstream target kinases.
Ahmed, M. I. et al. MicroRNA-214 controls skin and hair follicle development by modulating the activity of the Wnt pathway.
Here we report that metformin induces genome-wide alterations in DNA methylation by modulating the activity of S-adenosylhomocysteine hydrolase (SAHH).
Many non-coding genetic variants within risk-associated loci alter gene expression by modulating the activity of cis-regulatory elements.
We conclude that manganese regulates cytoskeletal organization in astrocytes by modulating the activity of p115RhoGEF and RhoA.
4-Me, an amino endoperoxide, can promote cell death in NOX4 overexpressed cancer cells by modulating the activity of NOX4.178 NAC or NOX4-targeted siRNA can abolish the pro-apoptosis activity of 4-Me.
Taken together, these results suggest that bone marrow-derived stem cells are the source of microcalcifications, and metastatic tumor cells may affect the 'vicious cycle' by modulating the activity of osteoblasts and osteoclasts.
These diverse modifications are read out by effector protein complexes, which ultimately determine their functional outcome by modulating the activity state of underlying genes.
Impaired differentiation of Tet2-ablated cells could be relieved or further exacerbated by modulating the activity of other TET family members, and mechanistically it could be linked to the dysregulated expression of C/EBP family transcription factors.
