Neuropeptides are believed to modulate secretion of classical neurotransmitters [ 79].
Neuropeptide co-transmitters present in autonomic nerves also modulate secretion by salivary glands (Ekström 1999).
We hypothesized that chitin exposure activates innate immune responses of keratinocytes by modulating chemokine secretion and TLR expression.
Miyamoto et al. found that resistin may increase the susceptibility of metabolic syndrome by modulating adiponectin secretion from adipocytes [ 58].
Ginger inhibits growth and modulates secretion of angiogenic factors in ovarian cancer cells.
It is therefore possible that MISC-1/OGC affects insulin secretion by modulating the function of Bcl-2 proteins, probably through regulation of Ca2+ release from mitochondrial stores.
In particular, miR-375 can influence glucose-induced insulin secretion by modulating the expression of myotrophin, a protein potentially involved in cytoskeleton dynamics (Poy et al., 2004).
In addition to this pulmonary mechanism, the renal tubular system is extremely well equipped to maintain the acid base balance of the extracellular compartment by modulating the reabsorption of bicarbonate and the secretion of protons.
SPARC may promote vascularisation of tumours, tumour progression, or invasiveness by modulating the activity of cytokines and stimulating secretion of tissue remodelling metalloproteases (Lane and Sage, 1994; Motamed and Sage, 1997; Sage, 1997).
It was found that TMEM106B may also contribute to the risk of developing FTLD in carriers of GRN mutations [ 165] possibly by modulating the levels of GRN secretion [ 26], however, other studies were not consistent with these findings [ 84, 169].
