Sentence examples for by modulating rates of from inspiring English sources

Primarily, the causes of OA are aging, obesity, mechanical stress [ 1], oxidative stress [ 2] and altered nutrient levels [ 3], all of which have been found to affect matrix composition, presumably by modulating rates of macromolecular biosynthesis and degradation.

As more susceptibility loci are identified for common human diseases it is becoming apparent that the majority of associated alleles contribute to disease risk by influencing gene expression, typically by modulating rates of transcription or of transcript stability (Ref. 45).

As more susceptibility loci are identified for common human diseases it is becoming clear that many, if not the majority, of associated alleles contribute to disease risk by influencing gene expression, typically by modulating rates of transcription or transcript stability [ 10, 11].

These stresses were observed to increase the frequency of switching to the opaque phase, raising the possibility that Candida cells may respond to the innate immune system by modulating their rates of white-opaque switching [11].

Receptors respond to stimuli by modulating their rates of switching between active and inactive conformations.

Because DNA methylation can affect the relative steady-state levels of RNA by modulating the rate of progression of the RNA polymerase II (RNA Pol II) complex in diverse ways [ 62, 63], we hypothesize that the 41 intragenic MbMt-hypermethylated DNA sites in these three overlapping genes help regulate differential splicing in this region through effects on RNA Pol II elongation.

In the present work, we demonstrate that SCD1, a key enzyme in the biosynthesis of MUFA, controls glucose-mediated lipogenesis by modulating the rate of synthesis of fatty acids, thereby providing cancer cells with the necessary lipid structures and signals to sustain their fast replication rate.

It is therefore plausible that LUAT expression might reflect a dedicated mechanism to induce stochastic expression of developmental regulators by modulating the rate of pervasive (i.e. non-productive) transcription.

This work supports the view that SCD1 regulates mitogenesis by modulating the rate of fatty acid synthesis, by preventing the toxic accumulation of SFA, and by controlling the supply of MUFA substrates required for lipid biosynthesis and cancer cell proliferation.

Therefore, it was preferable to pursue a form of filgrastim with a longer elimination half-life; achievable by modulating the rate of filgrastim clearance.

Several lines of evidence from our results support the idea that the M3 motif of PIN2 is involved in PIN2 degradation, in particular, by modulating the rate of vacuolar lytic trafficking at least in the root hair cell.