Sentence examples for by modulating protein expression from inspiring English sources
These results suggest that miRNAs contribute to psoriasis pathogenesis by modulating protein expression and cellular functions in both keratinocytes and infiltrating immune cells.
If miRNAs are involved in regulating hES cell differentiation by modulating protein expression, then levels of miRNA expression would change when hES cells are induced to differentiate.
Yeast is an adaptive organism that survives in a variety of environments by modulating protein expression and activity, such as during the fermentation phase [25] where the natural habitat of the yeast is commonly the acidic surrounding of a fruit or within its confines.
In addition to biochemical stimuli, muscle cells respond to biomechanical stimuli by modulating protein expression through activation of signaling pathways [ 89, 90].
In contrast, few changes in mRNA abundance are observed, indicating that regulation of translation is the primary mechanism of modulating protein expression during mitosis.
These findings underline the role of Bcl-xL protein as a resistance factor in colon cancer and as an attractive target for therapeutic concepts capable of specifically modulating protein expression such as in AS oligonucleotides strategies.
It is also noteworthy that, in addition to its transcriptional coactivator role, CARM1 also regulates target gene expression by modulating protein stability, including p/CIP [ 27], AP-1 [ 28], and NF-κB [ 29].
The mammalian target of rapamycin (mTOR) is a serine/threonine protein kinase that regulates cell growth and proliferation by modulating protein synthesis and transcription.
Consistent with a role for mTOR in regulating cell size by modulating protein synthesis, we also observed a larger morphology for the SIRT1 deficient MEFs compared to WT MEFs (Figure 1D).
Activation of mTORC1 regulates cell growth by modulating protein synthesis, ribosome biogenesis and autophagy [ 29].
By modulating protein tyrosine phosphatase activity, ROS may influence cellular growth and proliferation (Chiarugi and Cirri 2003).
