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Data from our studies thus far show that MS4a4B inhibits cell cycle progression of T cells possibly by modulating levels of cell cycle regulatory elements.
Our data suggest re-establishment of CXCL12 expression in colorectal carcinomas potentially serves as a target to sensitize these cells to chemotherapies while limiting metastatic progression by modulating levels of Bcl-2 family members.
Our results suggest that PKV regulates plant development by modulating levels of GA and the enzymes involved in GA biosynthesis.
Nutrient levels are known to influence the development of osteoarthritis (OA), presumably by modulating levels of matrix biosynthesis and degradation.
The ability to adjust membrane fluidity by modulating levels of unsaturated fatty acids is a feature of freezing-tolerant plants.
For example, the mammalian splicing factor SC35 self-regulates its expression by modulating levels of unproductive splicing of the 3' UTR of its own pre-mRNA [ 29].
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We recently identified USP19 as a DUB that indirectly modulates levels of p27Kip1 by a novel mechanism [20].
Moreover, the mRNA levels of many genes implicated in survival/apoptotic decision displayed modulated levels of expression by H19 knockdown in hypoxic stress.
This can be achieved, for instance, by modulating the levels of NUMB, by RNA interference and/or overexpression experiments, and checking the levels of TP53.
It has been suggested that one of the ways in which Mtb represses the pro-inflammatory responses at the site of infection is by modulating the levels of Ca2+ [34].
Since miRNAs largely act as 'early' regulators of signal transduction by modulating the levels of transcription factors, we chose to construct the library from soybean roots 3 h post rhizobial inoculation.
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