Sentence examples for by modulating endothelial cell from inspiring English sources
In addition, ADM has a regulatory function in angiogenesis by modulating endothelial cell behavior.
The inhibition of Rho-kinase protects the cerebral barrier from ischemia-evoked injury by modulating endothelial cell oxidative stress and tight junctions [ 61] and protects the structure and function of cardiac mitochondria from diabetes by attenuating oxidative stress [ 62].
They are found to be closely related to epidermal cell proliferation, and some of them have been found to play an important role in angiogenesis by modulating endothelial cell migration and proliferation [ 24– 28].
To evaluate whether 13-S-HODE can also influence the tumor microenvironment by modulating endothelial cell proliferation and migration, we added 13-S-HODE to HUVEC culture medium grown under hypoxia.
This suggests that this agent exerts its effects by blocking vasodilatation and the changes in permeability that aid the process of vessel co-option and increase diffusion of nutrients to the tumour, as well as by modulating endothelial cell proliferation.
Induction of angiogenesis may be due to NOX1 expression by LLC1 tumors, producing high amounts of ROS in the tumor microenvironment and modulating endothelial cell functions.
Indeed, a role for ADAM17 in modulating endothelial cell sprouting and ability to invade was recently suggested in cultured human endothelial cells in which ADAM17 expression was silenced by delivery of either siRNA or dominant negative constructs [8], [9].
In this study, we show that different VEGF-A isoforms have differing capabilities to modulate endothelial cell migration by regulating the activation and nuclear localisation of a key transcription factor (Fig. 7).
The expression of miR-21 seems to be induced in endothelial cells by shear stress and regulates the function of vascular smooth muscle cells by modulating endothelial nitric oxide synthase (eNOS) activity [ 89].
