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The enzymatic activation of eNOS is achieved by modulating activities of PP2A and AMPK, resulting in specific changes in eNOS phosphorylation at Ser and Thr.
Therefore, OsCYP2 may be a key regulator that controls ROS level by modulating activities of antioxidant enzymes at translation level.
Together, these data suggest that OsCYP2 may act as a key regulator that controls ROS level by modulating activities of antioxidant enzymes at translation level.
Collectively, these observations suggest that the microvesicle-enriched genes may contribute to the increased cell proliferation of target cells during tumor progression by modulating activities of cell cycle-related pathways.
ROS are proposed to be key signalling agents induced by respiratory inhibition, as they function both directly on the cell cycle and by modulating activities of plant growth regulators such as ethylene, abscisic acid and auxin (Ophir et al., 2009).
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This role is accomplished by regulation of the expression of transmembrane P carriers and by modulating activity of the hydroxylases that activate or catabolize vitamin D. All of these FGF23 effects are obtained through activation of specific receptors.
To examine whether PTEN promotes AIY neurite outgrowth by modulating activity of the PI3K pathway, we conducted an epistatic analysis of PTEN and PI3K pathway components.
Additionally, cigarette smoke may affect the pharmacokinetics of inhaled drugs by modulating activity of specific drug metabolizing enzymes (Durak et al. 1996).
Therefore, it is worthwhile to address this issue in terms of circumventing transporter-mediated MDR acquired by cancer cells by modulating activity of MDR transporters such as BCRP to sensitize cancer stem cells to conventional cancer chemotherapeutic agents and to efficiently eradicate them from tumor mass, thereby providing a clinical benefit for patients.
LPS can modulate activity of cPLA2 by phosphorylation [ 20].
Moreover this can be achieved by modulating the activities of a small number of specific growth factors either through their addition to the medium or their pharmacological inhibition (for summary see Figure 5).
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