Chromatin dynamics tightly controls activation and function of genes, by modulating the access of regulatory factors to DNA, and highly influences cellular behavior of normal and neoplastic cells [ 21].
Perilipins also regulate lipolysis by modulating the access of hormone sensitive lipases (HSL) to the surface of lipid droplet [ 47].
Firstly, Translation Factor eIF6, also demonstrated in the western blot, which can regulate translation by modulating the access of the large ribosomal subunits to the elongation cycle, binds to 60S subunits which are activated by release of eIF6 [ 48].
Together, these findings suggest that VEGF-mediated structural changes at the brain-hypothalamic barrier, by modulating the access of blood-borne metabolic substrates to the ARH, play an important role in the adaptive response to fasting.
Combining the results of this study with those by [23], I hypothesize that MicA-mediated processing of the luxS mRNA modulates access of the downstream-acting CyaR to the translation initiation region (TIR).
While little variation in metformin plasma pharmacokinetics was explained by polymorphisms in OCT1, polymorphisms in that gene appeared to modulate appeared to modulate the access of metformin to its target sites in the liver cell [ 63].
Brahma-associated factor (BAF) complexes are members of SWI/SNF ATP-dependent chromatin-remodeling family and regulate access of transcription factors by modulating chromatin structure.
They also regulate basic genomic processes such as transcription, replication and recombination, either directly by controlling the physical access of regulators to DNA or indirectly by modulating their binding through a complex repertoire of histone modifications [ 1].
This physical barrier modulates the access of insulin vesicles to the plasma membrane hence hampering exocytosis [25], [33].
Nucleosomes facilitate the packaging of the eukaryotic genome and modulate the access of regulators to DNA.
